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Biomolecular Target

When a molecular target is well characterized, a drug design based on a structure or homology model is appropriate. If the customer has access to the pure biomolecular target, it is necessary to use X-ray crystallography, NMR or other methods that can be planned. When the detailed molecular architecture is unknown, inferences from pharmacophore models developed on the basis of structure-activity data can serve as the approach to enhance both potency and selectivity for the desired target. Adding conformational constraints and modifying pharmacophoric groups is a fruitful approach.